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d 7 cholesterol  (Croda International Plc)

 
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    Croda International Plc d 7 cholesterol
    D 7 Cholesterol, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 91/100, based on 60 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/d 7 cholesterol/product/Croda International Plc
    Average 91 stars, based on 60 article reviews
    d 7 cholesterol - by Bioz Stars, 2026-06
    91/100 stars

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    Cambridge Isotope Laboratories 25,26,26,26,27,27,27- 2 h 7 ]cholesterol (d 7 -cholesterol)
    Experimental paradigms for different measurements. A: Tissue sterol levels in hamsters on a normal diet (ND) plus fat- and <t>cholesterol-containing</t> oral gavage (FCCOG). B: Tissue sterol levels in mice on ND. C: Tissue cholesterol input comprised of in situ biosynthesis and uptake of the synthesized cholesterol from the systemic circulation. D: Relative deuterium enrichment of 24-hydroxycholesterol. E: Tissue uptake of dietary cholesterol. D 2 O, deuterated water; D 7 -FCCOG, FCCOG containing deuterated cholesterol.
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    Experimental paradigms for different measurements. A: Tissue sterol levels in hamsters on a normal diet (ND) plus fat- and cholesterol-containing oral gavage (FCCOG). B: Tissue sterol levels in mice on ND. C: Tissue cholesterol input comprised of in situ biosynthesis and uptake of the synthesized cholesterol from the systemic circulation. D: Relative deuterium enrichment of 24-hydroxycholesterol. E: Tissue uptake of dietary cholesterol. D 2 O, deuterated water; D 7 -FCCOG, FCCOG containing deuterated cholesterol.

    Journal: Journal of Lipid Research

    Article Title: Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

    doi: 10.1016/j.jlr.2023.100401

    Figure Lengend Snippet: Experimental paradigms for different measurements. A: Tissue sterol levels in hamsters on a normal diet (ND) plus fat- and cholesterol-containing oral gavage (FCCOG). B: Tissue sterol levels in mice on ND. C: Tissue cholesterol input comprised of in situ biosynthesis and uptake of the synthesized cholesterol from the systemic circulation. D: Relative deuterium enrichment of 24-hydroxycholesterol. E: Tissue uptake of dietary cholesterol. D 2 O, deuterated water; D 7 -FCCOG, FCCOG containing deuterated cholesterol.

    Article Snippet: [25,26,26,26,27,27,27- 2 H 7 ]Cholesterol (D 7 -cholesterol) was purchased from Cambridge Isotope Laboratories Inc., [25,26,26,26,27,27,27- 2 H 7 ]-sitosterol (D 7 -sitosterol) was from Toronto Research Chemicals Inc. [1,2,5,6- 2 H 4 ]Lathosterol (D 4 -lathosterol), [26,26,26,27,27,27- 2 H 6 ]desmosterol (D 6 -desmosterol), [25,26,26,26,27,27,27- 2 H 7 ]24HC and [26,26,26,27,27- 2 H 5 ]27HC were from CDN Isotopes (Pointe-Claire, Canada), 23,24-bisnor-5-cholenic acid-3β-ol from Steraloids (Newport, RI).

    Techniques: In Situ, Synthesized

    Effects of the fat- and cholesterol-containing oral gavage (FCCOG). A: Serum lipid profile measured by a clinical laboratory. B–D: Tissue sterols quantified by GS-MS. All data represent the mean ± SD of the measurements in individual hamsters; the number of animals (n) for each panel is indicated in the figure. Statistical significance was assessed by a two-tailed, unpaired Student’s t test. ∗ P ≤ 0.05; ∗∗ P ≤ 0.01; ∗∗∗ P ≤ 0.001. 27COOH, cholestenoic acid; 27HC, 27-hydroxycholesterol; HDL, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; TG, triglycerides.

    Journal: Journal of Lipid Research

    Article Title: Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

    doi: 10.1016/j.jlr.2023.100401

    Figure Lengend Snippet: Effects of the fat- and cholesterol-containing oral gavage (FCCOG). A: Serum lipid profile measured by a clinical laboratory. B–D: Tissue sterols quantified by GS-MS. All data represent the mean ± SD of the measurements in individual hamsters; the number of animals (n) for each panel is indicated in the figure. Statistical significance was assessed by a two-tailed, unpaired Student’s t test. ∗ P ≤ 0.05; ∗∗ P ≤ 0.01; ∗∗∗ P ≤ 0.001. 27COOH, cholestenoic acid; 27HC, 27-hydroxycholesterol; HDL, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; TG, triglycerides.

    Article Snippet: [25,26,26,26,27,27,27- 2 H 7 ]Cholesterol (D 7 -cholesterol) was purchased from Cambridge Isotope Laboratories Inc., [25,26,26,26,27,27,27- 2 H 7 ]-sitosterol (D 7 -sitosterol) was from Toronto Research Chemicals Inc. [1,2,5,6- 2 H 4 ]Lathosterol (D 4 -lathosterol), [26,26,26,27,27,27- 2 H 6 ]desmosterol (D 6 -desmosterol), [25,26,26,26,27,27,27- 2 H 7 ]24HC and [26,26,26,27,27- 2 H 5 ]27HC were from CDN Isotopes (Pointe-Claire, Canada), 23,24-bisnor-5-cholenic acid-3β-ol from Steraloids (Newport, RI).

    Techniques: Two Tailed Test

    A summary of experimental data and calculations

    Journal: Journal of Lipid Research

    Article Title: Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

    doi: 10.1016/j.jlr.2023.100401

    Figure Lengend Snippet: A summary of experimental data and calculations

    Article Snippet: [25,26,26,26,27,27,27- 2 H 7 ]Cholesterol (D 7 -cholesterol) was purchased from Cambridge Isotope Laboratories Inc., [25,26,26,26,27,27,27- 2 H 7 ]-sitosterol (D 7 -sitosterol) was from Toronto Research Chemicals Inc. [1,2,5,6- 2 H 4 ]Lathosterol (D 4 -lathosterol), [26,26,26,27,27,27- 2 H 6 ]desmosterol (D 6 -desmosterol), [25,26,26,26,27,27,27- 2 H 7 ]24HC and [26,26,26,27,27- 2 H 5 ]27HC were from CDN Isotopes (Pointe-Claire, Canada), 23,24-bisnor-5-cholenic acid-3β-ol from Steraloids (Newport, RI).

    Techniques: Concentration Assay, In Situ

    Tissue relative enrichments after 2 weeks of either D 2 O or D 7 -FCCOG administration. A: Whole-body water deuterium ([ 2 H]) enrichment from D 2 O. B: Tissue [ 2 H] enrichment from D 2 O. C: Tissue D 7 -cholesterol enrichment from D 7 fat- and cholesterol-containing oral gavage FCCOG. All data represent the means ± S.D. of the measurements in individual hamsters; the number of animals (n) is indicated in each panel.

    Journal: Journal of Lipid Research

    Article Title: Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

    doi: 10.1016/j.jlr.2023.100401

    Figure Lengend Snippet: Tissue relative enrichments after 2 weeks of either D 2 O or D 7 -FCCOG administration. A: Whole-body water deuterium ([ 2 H]) enrichment from D 2 O. B: Tissue [ 2 H] enrichment from D 2 O. C: Tissue D 7 -cholesterol enrichment from D 7 fat- and cholesterol-containing oral gavage FCCOG. All data represent the means ± S.D. of the measurements in individual hamsters; the number of animals (n) is indicated in each panel.

    Article Snippet: [25,26,26,26,27,27,27- 2 H 7 ]Cholesterol (D 7 -cholesterol) was purchased from Cambridge Isotope Laboratories Inc., [25,26,26,26,27,27,27- 2 H 7 ]-sitosterol (D 7 -sitosterol) was from Toronto Research Chemicals Inc. [1,2,5,6- 2 H 4 ]Lathosterol (D 4 -lathosterol), [26,26,26,27,27,27- 2 H 6 ]desmosterol (D 6 -desmosterol), [25,26,26,26,27,27,27- 2 H 7 ]24HC and [26,26,26,27,27- 2 H 5 ]27HC were from CDN Isotopes (Pointe-Claire, Canada), 23,24-bisnor-5-cholenic acid-3β-ol from Steraloids (Newport, RI).

    Techniques:

    A comparison of cholesterol input to the retina and brain in hamsters and mice

    Journal: Journal of Lipid Research

    Article Title: Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

    doi: 10.1016/j.jlr.2023.100401

    Figure Lengend Snippet: A comparison of cholesterol input to the retina and brain in hamsters and mice

    Article Snippet: [25,26,26,26,27,27,27- 2 H 7 ]Cholesterol (D 7 -cholesterol) was purchased from Cambridge Isotope Laboratories Inc., [25,26,26,26,27,27,27- 2 H 7 ]-sitosterol (D 7 -sitosterol) was from Toronto Research Chemicals Inc. [1,2,5,6- 2 H 4 ]Lathosterol (D 4 -lathosterol), [26,26,26,27,27,27- 2 H 6 ]desmosterol (D 6 -desmosterol), [25,26,26,26,27,27,27- 2 H 7 ]24HC and [26,26,26,27,27- 2 H 5 ]27HC were from CDN Isotopes (Pointe-Claire, Canada), 23,24-bisnor-5-cholenic acid-3β-ol from Steraloids (Newport, RI).

    Techniques: Comparison, Concentration Assay, In Situ

    Correlation analyses. A: Relative deuterium ([ 2 H]) enrichment of brain 24-hydroxycholesterol (24HC) versus relative [ 2 H] enrichment of brain cholesterol. B: Relative [ 2 H] enrichment of brain 24HC versus relative [ 2 H] enrichment of plasma 24HC. C: Relative [ 2 H] enrichment of brain cholesterol versus relative [ 2 H] enrichment of plasma 24HC. Each dot represents the measurements in individual hamster, a total of 10 measurements (hamsters) in each panel: 4 animals were on D 2 O for 13 days, 3 animals were on D 2 O for 24 days, and 3 animals were on D 2 O for 35 days. A Pearson correlation coefficient and P value were computed to assess the linear relationship between the two variables in each panel. Data were fit by simple linear regression; the regression equations are indicated in each panel.

    Journal: Journal of Lipid Research

    Article Title: Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

    doi: 10.1016/j.jlr.2023.100401

    Figure Lengend Snippet: Correlation analyses. A: Relative deuterium ([ 2 H]) enrichment of brain 24-hydroxycholesterol (24HC) versus relative [ 2 H] enrichment of brain cholesterol. B: Relative [ 2 H] enrichment of brain 24HC versus relative [ 2 H] enrichment of plasma 24HC. C: Relative [ 2 H] enrichment of brain cholesterol versus relative [ 2 H] enrichment of plasma 24HC. Each dot represents the measurements in individual hamster, a total of 10 measurements (hamsters) in each panel: 4 animals were on D 2 O for 13 days, 3 animals were on D 2 O for 24 days, and 3 animals were on D 2 O for 35 days. A Pearson correlation coefficient and P value were computed to assess the linear relationship between the two variables in each panel. Data were fit by simple linear regression; the regression equations are indicated in each panel.

    Article Snippet: [25,26,26,26,27,27,27- 2 H 7 ]Cholesterol (D 7 -cholesterol) was purchased from Cambridge Isotope Laboratories Inc., [25,26,26,26,27,27,27- 2 H 7 ]-sitosterol (D 7 -sitosterol) was from Toronto Research Chemicals Inc. [1,2,5,6- 2 H 4 ]Lathosterol (D 4 -lathosterol), [26,26,26,27,27,27- 2 H 6 ]desmosterol (D 6 -desmosterol), [25,26,26,26,27,27,27- 2 H 7 ]24HC and [26,26,26,27,27- 2 H 5 ]27HC were from CDN Isotopes (Pointe-Claire, Canada), 23,24-bisnor-5-cholenic acid-3β-ol from Steraloids (Newport, RI).

    Techniques: Clinical Proteomics

    A comparison of the whole-body cholesterol maintenance in mice, hamsters, and humans

    Journal: Journal of Lipid Research

    Article Title: Quantitative characterizations of the cholesterol-related pathways in the retina and brain of hamsters

    doi: 10.1016/j.jlr.2023.100401

    Figure Lengend Snippet: A comparison of the whole-body cholesterol maintenance in mice, hamsters, and humans

    Article Snippet: [25,26,26,26,27,27,27- 2 H 7 ]Cholesterol (D 7 -cholesterol) was purchased from Cambridge Isotope Laboratories Inc., [25,26,26,26,27,27,27- 2 H 7 ]-sitosterol (D 7 -sitosterol) was from Toronto Research Chemicals Inc. [1,2,5,6- 2 H 4 ]Lathosterol (D 4 -lathosterol), [26,26,26,27,27,27- 2 H 6 ]desmosterol (D 6 -desmosterol), [25,26,26,26,27,27,27- 2 H 7 ]24HC and [26,26,26,27,27- 2 H 5 ]27HC were from CDN Isotopes (Pointe-Claire, Canada), 23,24-bisnor-5-cholenic acid-3β-ol from Steraloids (Newport, RI).

    Techniques: Comparison, Expressing, In Situ